SCHEMBL22972758

SCHEMBL22972758

O=C(O)c1cc(C#Cc2ccc(-c3cc(-c4ccc(C#Cc5cc(C(=O)O)cc(C(=O)O)c5)cc4)cc(-c4ccc(C#Cc5cc(C(=O)O)cc(C(=O)O)c5)cc4)c3)cc2)cc(C(=O)O)c1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 5/20 0.49
P2RY14 Q15391 1/20 0.48
EGFR P00533 1/20 0.46
RARB P10826 1/20 0.44
RARG P13631 1/20 0.44
RXRA P19793 6/20 0.44
RXRB P28702 5/20 0.44
PTPN11 Q06124 1/20 0.42
KMO O15229 1/20 0.41
RXRG P48443 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17354676 1.00 DHODH (0.49) DHODHP2RY14EGFRRARBRARG
SCHEMBL17354678 0.92 P2RY14 (0.46) DHODHP2RY14EGFRRARBRARG
SCHEMBL21133397 0.89 EGFR (0.55) P2RY14EGFRRARBRARGRXRA
SCHEMBL18624975 0.88 EGFR (0.58) EGFRRARBRARGRXRARXRB
SCHEMBL20026783 0.88 EGFR (0.58) EGFRRARBRARGRXRARXRB
SCHEMBL18604545 0.88 RARB (0.50) P2RY14RARBRARGPTPN11
SCHEMBL5667683 0.87 DHODH (0.61) DHODHP2RY14EGFRRARBRARG
SCHEMBL30610351 0.87 DHODH (0.57) DHODHP2RY14EGFRRXRARXRB
SCHEMBL18688872 0.85 RXRA (0.53) P2RY14EGFRRARBRARGRXRA
SCHEMBL21133286 0.84 EGFR (0.58) EGFRRARBRARGRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12629639-B2 Spacer for a spiral wound membrane EVOVE LTD (GB) 2026-05-19 US disclosed
US-20250188521-A1 NUCLEIC ACID DELIVERY SCAFFOLDS Singular Genomics Systems, Inc. 2025-06-12 US disclosed
US-12188088-B1 Multiplexed targeted amplification of polynucleotides Singular Genomics Systems, Inc. (US) 2025-01-07 US disclosed
US-20240425919-A1 MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES FIRST-CITIZENS BANK & TRUST COMPANY 2024-12-26 US disclosed
EP-4422792-A1 MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES Singular Genomics Systems, Inc. (US) 2024-09-04 EP disclosed
US-20240240251-A1 MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES FIRST-CITIZENS BANK & TRUST COMPANY 2024-07-18 US disclosed
EP-4397399-A2 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2024-07-10 EP disclosed
US-20240157304-A1 SPACER FOR A SPIRAL WOUND MEMBRANE EVOVE LTD (GB) 2024-05-16 US disclosed
US-20240149223-A1 MEMBRANE DEVICE EVOVE LTD (GB) 2024-05-09 US disclosed
EP-4304765-A1 SPACER FOR A SPIRAL WOUND MEMBRANE Evove Ltd (GB) 2024-01-17 EP disclosed
US-20230399692-A1 NUCLEIC ACID DELIVERY SCAFFOLDS FIRST-CITIZENS BANK & TRUST COMPANY 2023-12-14 US disclosed
US-11795505-B2 Nucleic acid delivery scaffolds Singular Genomics Systems, Inc. (US) 2023-10-24 US disclosed
US-20230287491-A1 NUCLEIC ACID DELIVERY SCAFFOLDS FIRST-CITIZENS BANK & TRUST COMPANY 2023-09-14 US disclosed
WO-2023172665-A2 NUCLEIC ACID DELIVERY SCAFFOLDS Singular Genomics Systems, Inc. (US) 2023-09-14 WO disclosed
WO-2023076833-A1 MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES Singular Genomics Systems, Inc. (US) 2023-05-04 WO disclosed
WO-2022189793-A1 MEMBRANE DEVICE EVOVE LTD (GB) 2022-09-15 WO disclosed
WO-2022189785-A1 SPACER FOR A SPIRAL WOUND MEMBRANE EVOVE LTD (GB) 2022-09-15 WO disclosed
US-20210363619-A1 METHOD FOR TUNING THERMAL EXPANSION PROPERTIES IN AN ADDITIVE MANUFACTURING FEEDSTOCK MATERIAL NAT TECH & ENG SOLUTIONS SANDIA LLC (US) 2021-11-25 US disclosed
US-11118249-B1 Method for tuning thermal expansion properties in an additive manufacturing feedstock material NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) 2021-09-14 US disclosed
EP-3774001-A1 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2021-02-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12629639-B2 Spacer for a spiral wound membrane AQP1, AQP3, AQP4 DHODH 2238/4885P2RY14 4474/4885EGFR 1806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.