Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28375723 | 0.86 | GABRP (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5738088 | 0.84 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29078101 | 0.84 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28949438 | 0.82 | CYP4F2 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27710769 | 0.81 | OPRM1 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11115121 | 0.79 | NFKB1 (0.55) | MAPTKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL29077994 | 0.79 | CYP17A1 (0.49) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14480241 | 0.76 | NNMT (0.37) | NNMTOPRM1OPRD1OPRK1MKNK1 | |
| SCHEMBL9572467 | 0.76 | KMT2A (0.45) | NNMTOPRM1OPRD1OPRK1ACACB | |
| SCHEMBL22557500 | 0.76 | KDM4E (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114845996-B | Benzene ring-containing compound and application thereof | 武汉朗来科技发展有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116390917-A | MRGX2 antagonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-114845996-A | Compound containing benzene ring and application thereof | 武汉朗来科技发展有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2018233526-A9 | CSF1R INHIBITOR, AND MANUFACTURING METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |
| CN-110461849-B | CSF1R inhibitor and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |
| CN-105294736-B | CDK small molecule inhibitor compound and application thereof | 广东东阳光药业有限公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-110461849-A | A kind of CSF1R inhibitor and its preparation method and application | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |