Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22982373 | 0.87 | PNMT (0.36) | HTR5AESR1ESR2PTGDR2ABHD6 | |
| SCHEMBL22993223 | 0.81 | ESR2 (0.53) | ESR2ABHD6TMEM97SIGMAR1MAPT | |
| SCHEMBL29405534 | 0.81 | ESR2 (0.53) | ESR2ABHD6TMEM97SIGMAR1MAPT | |
| SCHEMBL16147790 | 0.79 | TMEM97 (0.41) | NPC1MEN1KMT2AHTR5APTGDR2 | |
| SCHEMBL22982032 | 0.74 | ERCC1 (0.36) | KMT2AESR1ESR2ABHD6ALDH1A1 | |
| SCHEMBL17462502 | 0.74 | ESR2 (0.48) | NPC1ESR2RAB9A | |
| SCHEMBL13082467 | 0.73 | RIPK1 (0.49) | NPC1MEN1KMT2AHTR5APTGDR2 | |
| SCHEMBL23013352 | 0.72 | L3MBTL1 (0.39) | NPC1MEN1KMT2AL3MBTL1ESR1 | |
| SCHEMBL22981727 | 0.71 | NPC1 (0.35) | NPC1MEN1KMT2AL3MBTL1HTR5A | |
| SCHEMBL18584701 | 0.71 | ABHD6 (0.43) | NPC1MEN1KMT2AABHD6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |