Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.78 |
| ▸ | RAB9A | P51151 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | PKM | P14618 | 2/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17491404 | 0.81 | MEN1 (0.61) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL15652156 | 0.79 | NPC1 (0.70) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL14083900 | 0.79 | NPC1 (0.69) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL17109838 | 0.78 | NPC1 (0.68) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL14027518 | 0.78 | NPC1 (1.00) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL22983004 | 0.78 | RAB9A (0.61) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL5384036 | 0.77 | ROCK2 (0.76) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL27754792 | 0.77 | ROCK2 (0.66) | NPC1RAB9AALDH1A1LMNAROCK2 | |
| SCHEMBL14082980 | 0.77 | NPC1 (0.70) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| Nicotinanilide SCHEMBL352439 | 0.77 | LMNA (0.83) | NPC1RAB9AALDH1A1LMNAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324899-A1 | COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE | METRO INTERNATIONAL BIOTECH, LLC | 2022-10-13 | — | — | US | disclosed |
| EP-4013766-A1 | COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE | Metro International Biotech, LLC (US) | 2022-06-22 | — | — | EP | disclosed |
| CN-114555619-A | Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide | 麦德龙国际生物科技有限责任公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021030551-A1 | COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE | METRO INTERNATIONAL BIOTECH, LLC (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324899-A1 | COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE | NQO1, NAMPT, NADK | NPC1 309/4885RAB9A 1443/4885ALDH1A1 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.