SCHEMBL2298411

SCHEMBL2298411

CC1([N+](=O)[O-])Oc2ccc(CO[C]=O)cc2O1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TLR3 O15455 2/20 0.34
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.32
ALOX15 P16050 1/20 0.32
ALOX12 P18054 1/20 0.32
CYP3A4 P08684 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
IDO1 P14902 1/20 0.30
CRHBP P24387 1/20 0.30
CRHR2 Q13324 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5859596 0.81 CYP3A4 (0.43) TLR3NPC1RAB9AHTTALOX15
SCHEMBL130857 0.80 ALOX15 (0.38) TLR3NPC1RAB9AMAPTALDH1A1
SCHEMBL636947 0.74 DRD5 (0.31) CYP3A4
SCHEMBL1428264 0.71 CYP1A2 (0.36) CYP1A2CYP2C9CYP2C19
SCHEMBL9117904 0.69 CYP3A4 (0.36) CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL1211 0.69 IDO1 (0.61) RAB9AMAPTALDH1A1CYP1A2CYP2C9
SCHEMBL10335845 0.68 TSHR (0.43) MAPTALDH1A1HTTCYP3A4IDO1
SCHEMBL669225 0.68 CYP3A4 (0.59) NPC1RAB9AMAPTALDH1A1CYP3A4
SCHEMBL96363 0.67 TSHR (0.57) RAB9AMAPTALDH1A1ALOX15MEN1
SCHEMBL633797 0.66 ALDH1A1 (0.46) MAPTALDH1A1HTTALOX15CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110201528-A1 Methods Of Forming An Oligomer Array KUMHO PETROCHEMICAL CO., LTD. (KP) 2011-08-18 US claimed
WO-2024047178-A1 A METHOD FOR SIMULTANEOUS SYNTHESIS OF A PLURALITY OF OLIGONUCLEOTIDES ELEVEN THERAPEUTICS LTD (IL) 2024-03-07 WO disclosed
US-20110201528-A1 Methods Of Forming An Oligomer Array KUMHO PETROCHEMICAL CO., LTD. (KP) 2011-08-18 US disclosed
US-20100280234-A1 Photocleavable Protecting Groups and Methods for Their Use AFFYMETRIX, INC. (US) 2010-11-04 US disclosed
US-7659050-B2 High resolution silicon-containing resist INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-02-09 US disclosed
US-7470783-B2 Photocleavable protecting groups and methods for their use AFFYMETRIX, INC. (US) 2008-12-30 US disclosed
US-20060275694-A1 High resolution silicon-containing resist INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2006-12-07 US disclosed
US-7144700-B1 Photolithographic solid-phase polymer synthesis AFFYMETRIX, INC. (US) 2006-12-05 US disclosed
US-20060147981-A1 Methods for array preparation using substrate rotation AFFYMETRIX, INC. (US) 2006-07-06 US disclosed
US-7005259-B1 Methods for array preparation using substrate rotation AFFYMETRIX, INC. (US) 2006-02-28 US disclosed
US-5874589-A Methods for synthesizing diverse collections of tetramic acids and derivatives thereof GLAXO WELLCOME, INC. (US) 1999-02-23 US disclosed
WO-1998039348-A9 PHOTOCLEAVABLE PROTECTING GROUPS AND METHODS FOR THEIR USE 1999-02-18 WO disclosed
US-5846839-A Methods for hard-tagging an encoded synthetic library GLAXO GROUP LIMITED (GB) 1998-12-08 US disclosed
WO-1998039348-A1 PHOTOCLEAVABLE PROTECTING GROUPS AND METHODS FOR THEIR USE AFFYMETRIX, INC. (US) 1998-09-11 WO disclosed
US-5739386-A PHOTOCLEAVABLE LINKING GROUPS IN SOLID PHASE SYNTHESIS AFFYMAX TECHNOLOGIES N.V. (GB) 1998-04-14 US disclosed
WO-1997041093-A1 METHODS FOR THE SYNTHESIS OF FMOC PROTECTED AMINES AFFYMAX TECHNOLOGIES N.V. (GB) 1997-11-06 WO disclosed
EP-0776330-A2 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECHNOLOGIES N.V. (AN) 1997-06-04 EP disclosed
US-5549974-A IMMOBILIZATION AFFYMAX TECHNOLOGIES NV (AN) 1996-08-27 US disclosed
WO-1996000148-A1 METHODS FOR THE SOLID PHASE SYNTHESIS OF THIAZOLIDINONES, METATHIAZANONES, AND DERIVATIVES THEREOF AFFYMAX TECHNOLOGIES N.V. (AN) 1996-01-04 WO disclosed
WO-1996000378-A1 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECHNOLOGIES N.V. (AN) 1996-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280234-A1 Photocleavable Protecting Groups and Methods for Their Use RNF168, RTCB, C9 TLR3 1039/4885NPC1 4392/4885RAB9A 3325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.