Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL3810427 | 0.95 | AKR1B1 (0.43) | AKR1B1HPGDCYP2C19ADRA2BCYP2C9 | |
| SCHEMBL2788693 | 0.85 | HPGD (0.42) | AKR1B1HPGDCYP2C19CYP2C9CXCL8 | |
| SCHEMBL2745778 | 0.84 | MAPT (0.53) | AKR1B1HPGDCYP2C19CYP2C9TSHR | |
| SCHEMBL14221079 | 0.82 | HPGD (0.46) | AKR1B1HPGDCYP2C19CYP2C9SRC | |
| SCHEMBL4611520 | 0.81 | FFAR1 (0.56) | HPGDCYP2C19FFAR1FFAR4POLB | |
| SCHEMBL27877180 | 0.80 | FFAR1 (0.48) | AKR1B1HPGDCYP2C19FFAR1FFAR4 | |
| SCHEMBL29459931 | 0.80 | TSHR (0.53) | AKR1B1CXCL8TSHR | |
| SCHEMBL503325 | 0.80 | TSHR (0.53) | AKR1B1CXCL8TSHR | |
| SCHEMBL29393814 | 0.80 | HPGD (0.45) | AKR1B1HPGDCYP2C19CYP2C9SRC | |
| SCHEMBL987449 | 0.80 | HPGD (0.45) | AKR1B1HPGDCYP2C19CYP2C9SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103012111-A | Preparation method 2,4,5-trifluorophenylacetic acid | UNIV QUZHOU | 2013-04-03 | — | — | CN | claimed |
| US-20210171471-A1 | Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Uses Thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-06-10 | — | — | US | disclosed |
| CN-103012111-B | A kind of preparation method of 2,4,5-trifluoro benzene acetic acid | QUZHOU UNIVERSITY (CN) | 2016-01-13 | — | — | CN | disclosed |
| WO-2014125426-A1 | TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014125426-A1 | TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |
| EP-2098517-B1 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE | MSD KK (JP) | 2013-12-18 | — | — | EP | disclosed |
| US-20130261185-A1 | Benzamide Derivatives As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2013-10-03 | — | — | US | disclosed |
| CN-103012111-A | Preparation method 2,4,5-trifluorophenylacetic acid | UNIV QUZHOU | 2013-04-03 | — | — | CN | disclosed |
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| US-8367708-B2 | Phenyl-isoxazol-3-ol derivative | MSD K.K. (JP) | 2013-02-05 | — | — | US | disclosed |
| CN-101415678-A | Benzo (F) isoindol-2-ylphenylacetic acid derivatives as EP4Receptor agonists | GLAXO GROUP LTD (GB) | 2009-04-22 | — | — | CN | disclosed |
| EP-1979317-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |
| EP-1979316-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |
| US-20080167377-A1 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| WO-2008071736-A1 | BENZAMIDE DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-19 | — | — | WO | disclosed |
| WO-2007088189-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007088190-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007088190-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
| US-4333940-A | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development | AMERICAN CYANAMID COMPANY (US) | 1982-06-08 | — | — | US | disclosed |
| US-4243609-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167377-A1 | Novel compounds | F12, C1R, MRGPRX1 | AKR1B1 1541/4885HPGD 2744/4885CYP2C19 103/4885 |
| US-20210171471-A1 | Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Uses Thereof | RORB, RORA, RORC | AKR1B1 420/4885HPGD 1858/4885CYP2C19 380/4885 |
| US-20130261185-A1 | Benzamide Derivatives As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | AKR1B1 1653/4885HPGD 748/4885CYP2C19 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.