Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA3 | P07451 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 3/20 | 0.52 |
| ▸ | CA6 | P23280 | 3/20 | 0.52 |
| ▸ | CA5A | P35218 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | TYR | P14679 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298611 | 1.00 | APP (0.52) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL4375359 | 0.84 | APP (0.54) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL28760348 | 0.84 | CA12 (0.40) | CA12CA1CA9LMNATDP1 | |
| SCHEMBL10369661 | 0.80 | CA2 (0.50) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL31051124 | 0.80 | APP (0.50) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL10369660 | 0.80 | CA2 (0.50) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL2453590 | 0.80 | CYP19A1 (0.50) | APPALDH1A1MAPTCYP2C9CA12 | |
| SCHEMBL7053665 | 0.80 | CA12 (0.38) | APPKDM4EALDH1A1MAPTCYP2C9 | |
| SCHEMBL14297485 | 0.80 | LMNA (0.53) | ALDH1A1MAPTCA1CA2MAOB | |
| SCHEMBL2173890 | 0.80 | LMNA (0.53) | ALDH1A1MAPTCA1CA2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102883602-B | Method for reducing virulence of bacteria | UWM研究基金会有限公司 | 2017-07-18 | — | — | CN | disclosed |
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| CN-102883602-A | Method for reducing virulence of bacteria | UWM RES FOUNDATION INC | 2013-01-16 | — | — | CN | disclosed |
| EP-2536275-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | UWM Research Foundation, Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| WO-2011103189-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | UWM RESEARCH FOUNDATION, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | PGLS, RRS1, MRPL21 | APP 4873/4885KDM4E 4188/4885ALDH1A1 4049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.