Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22064051 | 0.81 | TERT (0.52) | TERTKMT2AMEN1TOP2ATOP2B | |
| SCHEMBL22987302 | 0.78 | KDM4E (0.38) | LMNATERTKMT2AMEN1ALDH1A1 | |
| SCHEMBL20051422 | 0.78 | MEN1 (0.47) | LMNAKMT2AMEN1HPGDGAA | |
| SCHEMBL17570931 | 0.73 | RECQL (0.47) | LMNAKMT2AMEN1GAA | |
| SCHEMBL22064568 | 0.73 | ALDH1A1 (0.66) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7142749 | 0.72 | MEN1 (0.43) | LMNAKMT2AMEN1GAA | |
| SCHEMBL17570922 | 0.70 | PDK1 (0.33) | KMT2ATOP2ATOP2B | |
| SCHEMBL17570905 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4EPOLB | |
| SCHEMBL18924126 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4EPOLB | |
| SCHEMBL6018151 | 0.68 | EPHX2 (0.53) | LMNAKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778601-A1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | ImmunoGen, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |