Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17570931 | 0.81 | RECQL (0.47) | LMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL22064051 | 0.80 | TERT (0.52) | KMT2APOLBMEN1ALDH1A1PKM | |
| SCHEMBL22987301 | 0.78 | LMNA (0.41) | KDM4EMAPTLMNAHPGDKMT2A | |
| SCHEMBL17570905 | 0.77 | ALDH1A1 (0.48) | KDM4EPOLBALDH1A1 | |
| SCHEMBL18924126 | 0.77 | ALDH1A1 (0.48) | KDM4EPOLBALDH1A1 | |
| SCHEMBL29329237 | 0.74 | L3MBTL1 (0.46) | HPGDKMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL22064568 | 0.72 | ALDH1A1 (0.66) | LMNAKMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL17570922 | 0.71 | PDK1 (0.33) | KMT2A | |
| SCHEMBL24239916 | 0.71 | CA12 (0.51) | KDM4ELMNAKMT2APOLBMEN1 | |
| SCHEMBL19463069 | 0.69 | HDAC8 (0.54) | HPGDKMT2AMEN1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778601-A1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | ImmunoGen, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |