SCHEMBL22987646

SCHEMBL22987646

O=c1[nH]c2c(C(F)(F)F)cccc2c2nc(-c3ccc(Cl)cc3OC(F)F)nn12

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
XDH P47989 3/20 0.39
ADORA3 P0DMS8 1/20 0.39
HAVCR2 Q8TDQ0 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29646335 1.00 XDH (0.39) XDHADORA3HAVCR2
SCHEMBL22988015 0.89 XDH (0.41) XDHADORA3HAVCR2
SCHEMBL22988092 0.87 XDH (0.41) XDHADORA3HAVCR2
SCHEMBL22987948 0.83 GABRP (0.54) ADORA3HAVCR2
SCHEMBL22987643 0.81 HSD11B1 (0.35)
SCHEMBL22987735 0.80 XDH (0.55) XDH
SCHEMBL22979408 0.78 XDH (0.41) XDHADORA3HAVCR2
SCHEMBL29646387 0.78 XDH (0.41) XDHADORA3HAVCR2
SCHEMBL22987718 0.75 SMN1; SMN2 (0.40) XDHHAVCR2
SCHEMBL29645469 0.75 P2RX7 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021028382-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES BAYER AKTIENGESELLSCHAFT (DE) 2021-02-18 WO disclosed