Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21845543 | 0.82 | USP30 (0.37) | HTR7USP30UCHL1LOXL2HSD17B1 | |
| SCHEMBL980817 | 0.81 | HTR7 (0.50) | HTR7USP30UCHL1KDRERCC5 | |
| SCHEMBL28539999 | 0.72 | KDR (0.46) | HTR7USP30UCHL1KDRHSD17B1 | |
| SCHEMBL21962876 | 0.70 | USP30 (0.47) | HTR7USP30UCHL1KDRERCC5 | |
| SCHEMBL17107113 | 0.68 | RAB9A (0.52) | USP30UCHL1HSD17B1HSD17B2 | |
| SCHEMBL27554467 | 0.68 | KDR (0.44) | USP30UCHL1KDRERCC5FEN1 | |
| SCHEMBL2410374 | 0.68 | HSD17B1 (0.56) | HTR7USP30KDRLOXL2HSD17B1 | |
| SCHEMBL146522 | 0.67 | KDR (0.52) | HTR7KDRERCC5FEN1GSTO1 | |
| SCHEMBL27778804 | 0.67 | KDR (0.52) | HTR7KDRERCC5FEN1GSTO1 | |
| SCHEMBL27570599 | 0.67 | HSD17B1 (0.42) | USP30UCHL1KDRERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3394049-B1 | CYANOPYRROLIDINE DERVIVATIVES AS INHBITORS FOR DUBS | MISSION THERAPEUTICS LTD (GB) | 2021-02-17 | — | — | EP | disclosed |
| WO-2017109488-A1 | CYANOPYRROLIDINE DERVIVATIVES AS INHIBITORS FOR DUBS | MISSION THERAPEUTICS LIMITED (GB) | 2017-06-29 | — | — | WO | disclosed |