Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561310 | 1.00 | PKM (0.50) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1403473 | 0.86 | TSHR (0.44) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL2424155 | 0.86 | TDP1 (0.44) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL10381810 | 0.86 | TSHR (0.44) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4663909 | 0.86 | TDP1 (0.46) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11225271 | 0.84 | MAPT (0.44) | PKMTDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL29112021 | 0.83 | PKM (0.46) | PKMTSHRTDP1ALDH1A1CYP1A2 | |
| SCHEMBL5275541 | 0.83 | TSHR (0.44) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4536570 | 0.83 | TSHR (0.44) | PKMTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL2259930 | 0.79 | TSHR (0.46) | PKMTSHRTDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194519-A | Benzobisimidazoles or benzothiazoles in polyether ketone or ether ether ketone polymers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1993-03-16 | — | — | US | claimed |
| US-11028103-B2 | Derivatized 3-styryl-cephalosporins | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2021-06-08 | — | — | US | disclosed |
| EP-3441071-A1 | DERIVATIZED CEPHALOSPORINS | Gladius Pharmaceuticals Corporation (CA) | 2019-02-13 | — | — | EP | disclosed |
| US-20180319817-A1 | Derivatized 3-Styryl-Cephalosporins | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2018-11-08 | — | — | US | disclosed |
| EP-2968352-B1 | DERIVATIZED 3-STYRYL-CEPHALOSPORINS | GLADIUS PHARMACEUTICALS CORP (CA) | 2018-09-26 | — | — | EP | disclosed |
| US-9975905-B2 | Derivatized 3-styryl-cephalosporins | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2018-05-22 | — | — | US | disclosed |
| EP-2536276-B1 | NOVEL BEXAROTENE ANALOGS | UNIV ARIZONA (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160031906-A1 | Derivatized 3-Styryl-Cephalosporins | SOPHARMIA, INC. | 2016-02-04 | — | — | US | disclosed |
| EP-2968352-A2 | DERIVATIZED 3-STYRYL-CEPHALOSPORINS | Gladius Pharmaceuticals Corporation (CA) | 2016-01-20 | — | — | EP | disclosed |
| US-9174917-B2 | Bexarotene analogs | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2015-11-03 | — | — | US | disclosed |
| WO-2014165126-A2 | DERIVATIZED 3-STYRYL-CEPHALOSPORINS | SOPHARMIA, INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| EP-2536276-A1 | NOVEL BEXAROTENE ANALOGS | The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120309833-A1 | NOVEL BEXAROTENE ANALOGS | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2012-12-06 | — | — | US | disclosed |
| WO-2011103321-A1 | NOVEL BEXAROTENE ANALOGS | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2011-08-25 | — | — | WO | disclosed |
| US-5194519-A | Benzobisimidazoles or benzothiazoles in polyether ketone or ether ether ketone polymers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1993-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031906-A1 | Derivatized 3-Styryl-Cephalosporins | SI, ENGASE, CMBL | PKM 3257/4885TSHR 4621/4885TDP1 2302/4885 |
| US-20180319817-A1 | Derivatized 3-Styryl-Cephalosporins | PEPD, SI, NAALAD2 | PKM 3165/4885TSHR 4568/4885TDP1 2757/4885 |
| US-11028103-B2 | Derivatized 3-styryl-cephalosporins | PEPD, SI, NAALAD2 | PKM 3165/4885TSHR 4568/4885TDP1 2757/4885 |
| US-20120309833-A1 | NOVEL BEXAROTENE ANALOGS | TBXA2R, ENPP2, CXCL8 | PKM 4567/4885TSHR 1215/4885TDP1 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.