Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124332 | 0.88 | ALDH1A1 (0.42) | HRH3ACHETSHRKCNA3CHRM5 | |
| SCHEMBL7124323 | 0.88 | ALDH1A1 (0.42) | HRH3ACHETSHRKCNA3CHRM5 | |
| SCHEMBL2299301 | 0.79 | ALDH1A1 (0.37) | HRH3TSHRCHRM5ADRA2CKDM4E | |
| SCHEMBL26497304 | 0.78 | SIGMAR1 (0.37) | KCNA3GPR119CHRM5 | |
| SCHEMBL277482 | 0.76 | LMNA (0.47) | HRH3TSHRCHRM5ADRA2CALDH1A1 | |
| SCHEMBL6199139 | 0.75 | TSHR (0.41) | HRH3ACHETSHRKCNA3GPR119 | |
| SCHEMBL9192552 | 0.74 | ACHE (0.52) | HRH3ACHETSHRCHRM5ADRA2C | |
| SCHEMBL4440646 | 0.74 | GNAI3 (0.42) | HRH3TSHRCHRM5ADRA2CSPHK1 | |
| SCHEMBL3469514 | 0.73 | HRH3 (0.43) | HRH3ACHEKCNA3CHRM5ADRA2C | |
| SCHEMBL24661180 | 0.73 | SMN1; SMN2 (0.45) | TSHRALDH1A1SPHK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |