Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18188099 | 0.85 | TRPA1 (0.57) | TRPA1ADORA2ARXRARXRBRXRG | |
| SCHEMBL30267490 | 0.85 | TRPA1 (0.57) | TRPA1ADORA2ARXRARXRBRXRG | |
| SCHEMBL18188108 | 0.77 | TRPA1 (0.56) | TRPA1TRPM8KDM4EMAPT | |
| SCHEMBL30272877 | 0.77 | TRPA1 (0.56) | TRPA1TRPM8KDM4EMAPT | |
| SCHEMBL761933 | 0.73 | DHFR (0.47) | ADORA2ANOS1 | |
| SCHEMBL2426591 | 0.69 | METAP2 (0.46) | TRPA1RXRARXRBRXRGNOS1 | |
| SCHEMBL35211775 | 0.69 | METAP2 (0.39) | TRPA1ADORA2ARXRARXRBRXRG | |
| SCHEMBL13731748 | 0.68 | HSD17B10 (0.54) | ADORA2AKDM4E | |
| SCHEMBL760372 | 0.66 | NOS1 (0.50) | NOS1KDM4EMAPT | |
| SCHEMBL18196425 | 0.65 | MAPKAPK2 (0.37) | TRPA1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107835814-B | Azabenzimidazoles and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-3288940-B9 | AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-21 | — | — | EP | disclosed |
| EP-3288940-B1 | AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-24 | — | — | EP | disclosed |