SCHEMBL2301770

SCHEMBL2301770

O=C(Cl)c1cc(C(=O)Cl)c(F)c(C(=O)Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
ALOX15 P16050 1/20 0.44
CES2 O00748 10/20 0.39
CES1 P23141 10/20 0.39
TSHR P16473 1/20 0.32
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA4 P22748 2/20 0.31
HDAC8 Q9BY41 1/20 0.31
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30
BCHE P06276 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5948933 0.88 CES2 (0.50) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL17262956 0.85 TPMT (0.46) ALDH1A1ALOX15CES2CES1TSHR
SCHEMBL16122066 0.81 ALDH1A1 (0.46) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL28634701 0.81 ALDH1A1 (0.36) ALDH1A1ALOX15TSHR
SCHEMBL193908 0.79 CES2 (0.64) ALDH1A1ALOX15CES2CES1TSHR
SCHEMBL7538844 0.79 ALDH1A1 (0.34) ALDH1A1ALOX15TSHR
SCHEMBL16098143 0.77 ALDH1A1 (0.43) ALDH1A1ALOX15CES2CES1
SCHEMBL16122567 0.77 ALDH1A1 (0.43) ALDH1A1ALOX15CES2CES1CA1
SCHEMBL6516614 0.77 ALDH1A1 (0.33) ALDH1A1ALOX15TSHR
SCHEMBL668724 0.77 TTR (0.39) ALDH1A1ALOX15CES2CES1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9056284-B2 Chlorine resistant amides, polyamides, and membranes made from the same THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) 2015-06-16 US claimed
US-20110203990-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME MURPHY ANDREW PATRICK 2011-08-25 US claimed
US-7806275-B2 Chlorine resistant polyamides and membranes made from the same THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR, THE BUREAU OF RECLAMATION (US) 2010-10-05 US claimed
WO-2008140840-A9 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME US GOV INTERIOR (US) 2009-03-12 WO claimed
WO-2008140840-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME GOVERNMENT OF THE USA AS REPRESENTED BY THE DEPARTMENT OF THE INTERIOR - BUREAU OF RECLAMATION (US) 2008-11-20 WO claimed
US-20080277333-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME SEPARATION SYSTEMS TECHNOLOGY INC. 2008-11-13 US claimed
US-20160074817-A1 Halogen Resistant Amides, Polyamides, and Membranes Made From the Same THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) 2016-03-17 US disclosed
US-9056284-B2 Chlorine resistant amides, polyamides, and membranes made from the same THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) 2015-06-16 US disclosed
US-9056284-B2 Chlorine resistant amides, polyamides, and membranes made from the same THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) 2015-06-16 US disclosed
US-9056284-B2 Chlorine resistant amides, polyamides, and membranes made from the same THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) 2015-06-16 US disclosed
US-20140042082-A1 CHLORINE RESISTANT AMIDES, POLYAMIDES, AND MEMBRANES MADE FROM THE SAME THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR 2014-02-13 US disclosed
US-20140042082-A1 CHLORINE RESISTANT AMIDES, POLYAMIDES, AND MEMBRANES MADE FROM THE SAME THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR 2014-02-13 US disclosed
US-20140042082-A1 CHLORINE RESISTANT AMIDES, POLYAMIDES, AND MEMBRANES MADE FROM THE SAME THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR 2014-02-13 US disclosed
WO-2008140840-A9 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME US GOV INTERIOR (US) 2009-03-12 WO disclosed
WO-2008140840-A9 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME US GOV INTERIOR (US) 2009-03-12 WO disclosed
WO-2008140840-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME GOVERNMENT OF THE USA AS REPRESENTED BY THE DEPARTMENT OF THE INTERIOR - BUREAU OF RECLAMATION (US) 2008-11-20 WO disclosed
WO-2008140840-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME GOVERNMENT OF THE USA AS REPRESENTED BY THE DEPARTMENT OF THE INTERIOR - BUREAU OF RECLAMATION (US) 2008-11-20 WO disclosed
US-20080277333-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME SEPARATION SYSTEMS TECHNOLOGY INC. 2008-11-13 US disclosed
US-20080277333-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME SEPARATION SYSTEMS TECHNOLOGY INC. 2008-11-13 US disclosed
US-20080277333-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME SEPARATION SYSTEMS TECHNOLOGY INC. 2008-11-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110203990-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME CLIC1, CLIC4, CLCN2 ALDH1A1 2858/4885ALOX15 3113/4885CES2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.