SCHEMBL668724

SCHEMBL668724

O=C(Cl)c1cc(Cl)c(F)c(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.39
TSHR P16473 2/20 0.38
CES2 O00748 2/20 0.37
CES1 P23141 2/20 0.37
ALDH1A1 P00352 4/20 0.36
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
KCNE1 P15382 1/20 0.33
KCNQ1 P51787 1/20 0.33
ALOX15 P16050 1/20 0.33
SRD5A2 P31213 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33
KMO O15229 2/20 0.32
DAO P14920 1/20 0.32
TPMT P51580 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
MAPT P10636 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7922027 0.89 CES2 (0.48) TTRTSHRCES2CES1ALDH1A1
SCHEMBL8840329 0.82 TTR (0.41) TTRTSHRCES2CES1ALDH1A1
SCHEMBL667661 0.80 TTR (0.62) TTRTSHRALDH1A1ALOX15SRD5A2
SCHEMBL10921198 0.79 TTR (0.48) TTRTSHRALDH1A1SRD5A2KMO
SCHEMBL983196 0.79 HPGD (0.46) TTRTSHRALDH1A1SRD5A2KMO
SCHEMBL15199066 0.78 CA5A (0.46) TTRTSHRCES2CES1ALDH1A1
SCHEMBL27851699 0.78 LMNA (0.44) TTRTSHRCES2CES1KDM4E
SCHEMBL104060 0.77 ALDH1A1 (0.54) TTRTSHRALDH1A1SRD5A2KMO
SCHEMBL193908 0.77 CES2 (0.64) TSHRCES2CES1ALDH1A1KCNQ3
SCHEMBL2301770 0.77 ALDH1A1 (0.44) TSHRCES2CES1ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121872907-A Method for co-producing 3-chloro-4-fluorobenzoyl chloride and 3, 5-dichloro-4-fluorobenzoyl chloride 湖北联昌新材料有限公司 2026-04-17 CN disclosed
CN-121872907-A Method for co-producing 3-chloro-4-fluorobenzoyl chloride and 3, 5-dichloro-4-fluorobenzoyl chloride 湖北联昌新材料有限公司 2026-04-17 CN disclosed
CN-120305914-B Bisamide compound and preparation method thereof, intermediate preparation equipment and application 山东华升新材料有限公司 2025-11-11 CN disclosed
CN-120305914-A Bisamide compound and preparation method thereof, intermediate preparation equipment and application 山东华升新材料有限公司 2025-07-15 CN disclosed
CN-116478134-A SSRI/5-HT 1A Double-target antidepressant formylpiperidine compound and preparation method and application thereof 上海医药工业研究院有限公司 2023-07-25 CN disclosed
EP-1601642-B1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX INTREXON CORP (US) 2017-01-04 EP disclosed
EP-1601642-B1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX INTREXON CORP (US) 2017-01-04 EP disclosed
EP-2463269-B1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORP (US) 2016-09-28 EP disclosed
US-9359289-B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORPORATION (US) 2016-06-07 US disclosed
US-9359289-B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORPORATION (US) 2016-06-07 US disclosed
WO-2004078924-A2 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RHEOGENE, INC. (US) 2004-09-16 WO disclosed
US-5981789-A CHLORODENITRATING AROMATIC COMPOUNDS USING LESS CHLORINATING AGENT AND LOWER TEMPERATURES, THEN RECYCLING THE PRODUCT MIXTURE TO INCREASE THE YIELD OCCIDENTAL CHEMICAL CORPORATION (US) 1999-11-09 US disclosed
US-4960768-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1990-10-02 US disclosed
US-4863954-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1989-09-05 US disclosed
US-4767757-A Acyloxythiophene-carboxamide fungicides, compositions and use BAYER AKTIENGESELLSCHAFT (DE) 1988-08-30 US disclosed
US-4704483-A FLUORINATION WITH POTASSIUM FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1987-11-03 US disclosed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP disclosed
US-4582948-A VAPOR PHASE CHLORO-DENITRATION REACTION OCCIDENTAL CHEMICAL CORPORATION (US) 1986-04-15 US disclosed
EP-0159388-A2 Preparation of nuclear chlorinated compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1985-10-30 EP disclosed
US-4470930-A Preparation of nuclear chlorinated aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1984-09-11 US disclosed