Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794884 | 0.78 | NPC1 (0.54) | LMNATP53MAPTHTTSMN1; SMN2 | |
| SCHEMBL9820200 | 0.76 | NPC1 (0.46) | LMNAMAPTHTTSMN1; SMN2KDM4E | |
| SCHEMBL23794877 | 0.76 | POLB (0.47) | LMNAMAPTHTTSMN1; SMN2KDM4E | |
| SCHEMBL23794881 | 0.76 | NPC1 (0.62) | LMNATP53MAPTHTTSMN1; SMN2 | |
| SCHEMBL3423042 | 0.74 | LPL (0.48) | LMNATP53MAPTHTTSMN1; SMN2 | |
| SCHEMBL23794883 | 0.72 | DHODH (0.49) | NPC1LRRK2 | |
| SCHEMBL17115796 | 0.71 | — | — | |
| SCHEMBL9418558 | 0.69 | LPL (0.43) | LMNATP53MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL22255199 | 0.68 | KDM4E (0.50) | LMNAHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL181171 | 0.68 | LRRK2 (0.40) | LMNAHTTSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782986-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-02-24 | — | — | EP | disclosed |