SCHEMBL23029977

SCHEMBL23029977

Cc1nc2c(Br)ccc(N(C)C)n2n1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HAVCR2 Q8TDQ0 3/20 0.35
HPGD P15428 2/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
PDE10A Q9Y233 5/20 0.33
HTR6 P50406 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
TP53 P04637 1/20 0.31
AHR P35869 1/20 0.31
PDE5A O76074 1/20 0.31
PDE4D Q08499 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23029998 0.82 PDE10A (0.34) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL23029946 0.78 HAVCR2 (0.39) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL24857434 0.77 HTR6 (0.32) HAVCR2PDE10AHTR6SMN1; SMN2HSD17B10
SCHEMBL23029979 0.75 HAVCR2 (0.37) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL23030300 0.63 ALOX15 (0.33) TSHR
SCHEMBL16565475 0.63 AHR (0.54) HAVCR2HPGDPDE10ASMN1; SMN2HSD17B10
SCHEMBL31330001 0.60 HPGD (0.36) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL31329841 0.60 HAVCR2 (0.36) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL31329986 0.60 HPGD (0.36) HAVCR2HPGDLMNATSHRPDE10A
SCHEMBL16439330 0.59 EGLN2 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583870-B2 Azaheteroaryl compound and application thereof SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) 2026-03-24 US disclosed
US-20230002414-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) 2023-01-05 US disclosed
US-20230002414-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) 2023-01-05 US disclosed
EP-4019521-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF Blueray Therapeutics (Shanghai) Co., Ltd (CN) 2022-06-29 EP disclosed
EP-4019521-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF Blueray Therapeutics (Shanghai) Co., Ltd (CN) 2022-06-29 EP disclosed
WO-2021032004-A9 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF 上海青煜医药科技有限公司 2021-03-25 WO disclosed
WO-2021032004-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF 上海青煜医药科技有限公司 2021-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230002414-A1 AZAHETEROARYL COMPOUND AND APPLICATION THEREOF EZH2, EED, SUZ12 HAVCR2 2990/4885HPGD 2809/4885LMNA 4362/4885
US-12583870-B2 Azaheteroaryl compound and application thereof NR3C1, EED, EZH2 HAVCR2 1076/4885HPGD 3579/4885LMNA 3329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.