Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 11/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304629 | 0.89 | CA1 (0.47) | ACVR1TGFBR1CA1CA2SUV39H2 | |
| SCHEMBL2302556 | 0.89 | ACVR1 (0.43) | ACVR1TGFBR1ACVR1BKCNH2BMPR1A | |
| SCHEMBL2301546 | 0.87 | ACVR1 (0.40) | ACVR1TGFBR1CA1CA2CA12 | |
| SCHEMBL2301153 | 0.84 | CA1 (0.43) | TGFBR1CA1CA2CA12CA9 | |
| SCHEMBL2302864 | 0.83 | EGFR (0.43) | CA1CA2CA12CA9SUV39H2 | |
| SCHEMBL14119629 | 0.83 | ACVR1 (0.41) | ACVR1TGFBR1ACVR1BKCNH2BMPR1A | |
| SCHEMBL2301941 | 0.83 | KDM4E (0.36) | ACVR1CA1CA2CA12CA9 | |
| SCHEMBL2301613 | 0.82 | TGFBR1 (0.42) | ACVR1TGFBR1CA1CA2CA9 | |
| SCHEMBL2300277 | 0.81 | CA12 (0.36) | ACVR1CA1CA2CA12CA9 | |
| SCHEMBL2237662 | 0.81 | PTGS2 (0.37) | CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536693-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | Université Laval (CA) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100840-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITé LAVAL (CA) | 2011-08-25 | — | — | WO | disclosed |