Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301546 | 0.91 | ACVR1 (0.40) | CA1CA2CA4CA7TGFBR1 | |
| SCHEMBL2302987 | 0.89 | PRKAB2 (0.42) | CA1CA2CA4CA7MAPKAPK2 | |
| SCHEMBL2301613 | 0.88 | TGFBR1 (0.42) | CA1CA2MAPKAPK2TGFBR1PTGS2 | |
| SCHEMBL2237662 | 0.87 | PTGS2 (0.37) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL2304629 | 0.87 | CA1 (0.47) | CA1CA2CA4CA7TGFBR1 | |
| SCHEMBL2299463 | 0.86 | CA12 (0.41) | CA1CA2CA7F10PTGS2 | |
| SCHEMBL2300517 | 0.86 | PTGS2 (0.41) | CA1CA2CA4CA7PTGS2 | |
| SCHEMBL2303495 | 0.86 | PTGES2 (0.37) | F10 | |
| SCHEMBL2303165 | 0.85 | CA12 (0.39) | CA1CA2CA12CA9 | |
| SCHEMBL2302226 | 0.85 | CA1 (0.34) | CA1CA2CA4CA7F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536693-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | Université Laval (CA) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100840-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITé LAVAL (CA) | 2011-08-25 | — | — | WO | disclosed |