Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 7/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301153 | 0.91 | CA1 (0.43) | TGFBR1TNFCA1CA2CA4 | |
| SCHEMBL2301613 | 0.90 | TGFBR1 (0.42) | ACVR1TGFBR1TNFCA1CA2 | |
| SCHEMBL2302730 | 0.89 | ACVR1 (0.38) | ACVR1TGFBR1RIPK2NOD2CYP1A1 | |
| SCHEMBL2303589 | 0.87 | ACVR1 (0.43) | ACVR1TGFBR1RIPK2CYP1A1CA1 | |
| SCHEMBL2301941 | 0.85 | KDM4E (0.36) | ACVR1CA1CA2SUV39H2CA12 | |
| SCHEMBL2304629 | 0.84 | CA1 (0.47) | ACVR1TGFBR1CA1CA2CA4 | |
| SCHEMBL2300277 | 0.83 | CA12 (0.36) | ACVR1CA1CA2SUV39H2EGFR | |
| SCHEMBL2237662 | 0.82 | PTGS2 (0.37) | CA1CA2CA12CA9 | |
| SCHEMBL2299883 | 0.82 | EIF2AK2 (0.41) | CA1CA2EGFRROS1ALK | |
| SCHEMBL2300517 | 0.81 | PTGS2 (0.41) | CA1CA2CA4CA7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536693-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | Université Laval (CA) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100840-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITé LAVAL (CA) | 2011-08-25 | — | — | WO | disclosed |