Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pimelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.71 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.77 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.75 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.75 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.75 |
| ▸ | PPARG | P37231 | 7/20 | 0.71 |
| ▸ | PPARD | Q03181 | 7/20 | 0.71 |
| ▸ | PPARA | Q07869 | 7/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.71 |
| ▸ | TLR2 | O60603 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | FABP4 | P15090 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1197865 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| Azelaic Acid SCHEMBL7203725 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| SCHEMBL3814949 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| Azelaic Acid SCHEMBL6462921 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| SCHEMBL3493631 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| SCHEMBL1235383 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| SCHEMBL25186232 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| Octanedioate SCHEMBL5799504 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| SCHEMBL21065467 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 | |
| Sebacic Acid SCHEMBL20500595 | 1.00 | TSHR (1.00) | TSHRLMNANFKB1PMP22SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073889-A | High polymer material with good water retention and preparation method thereof | 江苏睿安应用生物技术股份有限公司 | 2022-09-20 | — | — | CN | disclosed |
| US-20210246273-A1 | Cellulose Nanofiber-Containing Aqueous Dispersion | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2021-08-12 | — | — | US | disclosed |
| EP-3010956-B1 | HYPERBRANCHED POLYMERS | DSM IP ASSETS BV (NL) | 2020-04-29 | — | — | EP | disclosed |
| US-20200071733-A1 | RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE | LYGOS, INC. | 2020-03-05 | — | — | US | disclosed |
| EP-3404094-A1 | RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE | Lygos, Inc. (US) | 2018-11-21 | — | — | EP | disclosed |
| EP-2823032-B1 | RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE | LYGOS INC (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-3010956-A1 | HYPERBRANCHED POLYMERS | DSM IP Assets B.V. (NL) | 2016-04-27 | — | — | EP | disclosed |
| EP-2794729-B1 | HYPERBRANCHED POLYMERS | DSM IP ASSETS BV (NL) | 2016-04-13 | — | — | EP | disclosed |
| EP-2823032-A1 | RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE | Lygos, Inc. (US) | 2015-01-14 | — | — | EP | disclosed |
| EP-2822944-A1 | OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN, INC. (US) | 2015-01-14 | — | — | EP | disclosed |
| CN-101528993-A | Spandex fibers containing partially dehydroxylated hydrotalcite | HYOSUNG CORP (KR) | 2009-09-09 | — | — | CN | disclosed |
| US-6927237-B2 | Two solvent antimicrobial compositions and methods employing them | ECOLAB INC. (US) | 2005-08-09 | — | — | US | disclosed |
| US-20050096245-A1 | Two solvent antimicrobial compositions and methods employing them | ECOLAB INC. (US) | 2005-05-05 | — | — | US | disclosed |
| US-20020168422-A1 | Two solvent antimicrobial compositions and methods employing them | ECOLAB USA INC. | 2002-11-14 | — | — | US | disclosed |
| EP-1192178-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000078795-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078797-A1 | RUFOMYCIN DERIVATIVES USEFUL AS ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| US-5260120-A | Coating with primer, heating and drying, then applying protective coating yields zinc coated metal substrate which does not deteriorate welding electrode | MORTON INTERNATIONAL, INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0545605-A2 | Two coat weldable primer for steel | MORTON INTERNATIONAL, INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4175064-A | COBALT AND POTASSIUM CARBOXYLIC ACID SALTS | TENNECO CHEMICALS, INC. (US) | 1979-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071733-A1 | RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE | ME1, MAL2, ME3 | SLC6A2 3493/4885SLC6A3 4016/4885TSHR 2970/4885 |
| US-20020168422-A1 | Two solvent antimicrobial compositions and methods employing them | TAS2R50, HDHD5, CEL | SLC6A2 3165/4885SLC6A3 3507/4885TSHR 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.