Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MCOLN2 | Q8IZK6 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23379508 | 0.89 | MCOLN3 (0.56) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23057145 | 0.89 | L3MBTL1 (0.53) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL29979001 | 0.88 | MCOLN2 (0.47) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23043612 | 0.88 | ALDH1A1 (0.52) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23043701 | 0.88 | L3MBTL1 (0.49) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23043625 | 0.87 | ALDH1A1 (0.52) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23057180 | 0.87 | MCOLN3 (0.68) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23355024 | 0.86 | MCOLN3 (0.54) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23044597 | 0.86 | MCOLN3 (0.51) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 | |
| SCHEMBL23057085 | 0.85 | MCOLN3 (0.70) | MCOLN3L3MBTL1PKMMCOLN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| WO-2021094974-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
| WO-2021041866-A1 | SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | TRPM7, TRPM2, TRPM5 | MCOLN3 12/4885L3MBTL1 3739/4885PKM 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.