Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | GAA | P10253 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 7/20 | 0.64 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21467853 | 0.86 | LMNA (0.52) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL23094227 | 0.82 | CYP3A4 (1.00) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL23094204 | 0.82 | ALDH1A1 (1.00) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL23094192 | 0.82 | ALDH1A1 (1.00) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL23094206 | 0.81 | ALDH1A1 (0.79) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL23094200 | 0.80 | LMNA (0.74) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL11319999 | 0.79 | ALDH1A1 (0.57) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL187562 | 0.79 | LMNA (0.61) | ALDH1A1GAAMAPTCYP3A4LMNA | |
| SCHEMBL1033641 | 0.79 | LMNA (0.61) | ALDH1A1GAAMAPTCYP3A4CYP2C19 | |
| SCHEMBL29602721 | 0.79 | LMNA (0.61) | ALDH1A1GAAMAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | ALDH1A1 845/4885GAA 2121/4885MAPT 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.