Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094192 | 0.90 | ALDH1A1 (1.00) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094204 | 0.90 | ALDH1A1 (1.00) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094206 | 0.88 | ALDH1A1 (0.79) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094200 | 0.85 | LMNA (0.74) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094269 | 0.82 | ALDH1A1 (0.76) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094228 | 0.82 | ALDH1A1 (0.69) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL16930319 | 0.80 | CYP1A2 (0.66) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094254 | 0.79 | TP53 (0.71) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094178 | 0.79 | ALDH1A1 (1.00) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT | |
| SCHEMBL23094230 | 0.78 | L3MBTL1 (0.76) | CYP3A4CYP2C19CYP1A2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | CYP3A4 2609/4885CYP2C19 4648/4885CYP1A2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.