Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825836 | 0.84 | NCF1 (0.45) | KDM4ESMN1; SMN2MAPTALDH1A1DPP4 | |
| SCHEMBL29814673 | 0.81 | NCF1 (0.49) | HTR3AHRH4KDM4EADRA2CPOLB | |
| SCHEMBL20203510 | 0.81 | NCF1 (0.49) | HTR3AHRH4KDM4EADRA2CPOLB | |
| SCHEMBL18823165 | 0.81 | HTR3B (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL18291446 | 0.80 | DRD3 (0.50) | KDM4ESMN1; SMN2DRD2DRD3MAPT | |
| SCHEMBL2366124 | 0.79 | ADRB1 (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23103328 | 0.79 | HTR1A (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL20203393 | 0.79 | CDK4 (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL16041235 | 0.78 | HTR3E (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL16040183 | 0.76 | HTR3A (0.45) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |
| CN-105209468-A | Substituted 7-azabicycles and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |