Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093464 | 0.77 | KCNH2 (0.55) | PTGS1PTGS2KCNH2 | |
| SCHEMBL29802559 | 0.77 | KCNH2 (0.55) | PTGS1PTGS2KCNH2 | |
| SCHEMBL23110900 | 0.73 | KDM4E (0.40) | ALDH1A1L3MBTL1PTGS1PTGS2NPC1 | |
| SCHEMBL29473454 | 0.68 | GABRP (0.44) | SYKGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23093392 | 0.68 | CYP11B2 (0.45) | ALDH1A1L3MBTL1ALDH1A3ADORA3ADORA2A | |
| SCHEMBL2423171 | 0.66 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL21516056 | 0.65 | KCNH2 (0.46) | KIF20BADORA2AKCNH2 | |
| SCHEMBL3161378 | 0.65 | NOS3 (0.43) | SYKGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL4718764 | 0.64 | MEN1 (0.49) | ALDH1A1L3MBTL1PTGS2RAB9ASMN1; SMN2 | |
| SCHEMBL4764208 | 0.64 | ALDH1A3 (0.40) | SYKALDH1A1L3MBTL1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050700-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |