Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23112361 | 0.87 | HRH2 (0.43) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112637 | 0.86 | LMNA (0.43) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112760 | 0.85 | LMNA (0.42) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112518 | 0.80 | LMNA (0.38) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112475 | 0.79 | OPRD1 (0.40) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112375 | 0.76 | RORC (0.48) | RORCMEN1KMT2A | |
| SCHEMBL7425816 | 0.74 | SMN1; SMN2 (0.45) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112776 | 0.73 | HRH2 (0.44) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL23112649 | 0.73 | HSD11B1 (0.39) | MEN1KMT2AHSD11B1 | |
| SCHEMBL30148517 | 0.72 | OPRD1 (0.48) | LMNAPOLBSMN1; SMN2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793559-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2021-03-24 | — | — | EP | disclosed |