Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 15/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 13/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 14/20 | 0.49 |
| ▸ | CDK9 | P50750 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 10/20 | 0.45 |
| ▸ | CDK7 | P50613 | 10/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.45 |
| ▸ | CCNH | P51946 | 9/20 | 0.45 |
| ▸ | CCND1 | P24385 | 8/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30315529 | 1.00 | CDK1 (0.50) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL30315332 | 0.83 | CDK5 (0.53) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL2310970 | 0.83 | CDK5 (0.53) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL21017207 | 0.82 | CDK2 (0.52) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL2315371 | 0.81 | CDK2 (0.54) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL25308297 | 0.78 | CCNK (0.64) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL30518535 | 0.78 | CCNK (0.64) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL2318356 | 0.77 | AHR (0.51) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL30518560 | 0.77 | CDK2 (0.56) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL25309378 | 0.77 | CDK2 (0.56) | CDK1CCNB1CDK5CDK5R1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| EP-2788476-B1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | HUTCHINSON FRED CANCER RES (US) | 2019-05-22 | — | — | EP | disclosed |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2018-05-24 | — | — | US | disclosed |
| US-9834755-B2 | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-9580426-B2 | Compounds that expand hematopoietic stem cells | NOVARTIS AG (CH) | 2017-02-28 | — | — | US | disclosed |
| US-9567569-B2 | Methods of culturing and expanding mesenchymal stem cells | GAMIDA CELL LTD. (IL) | 2017-02-14 | — | — | US | disclosed |
| US-9175266-B2 | Enhancement of natural killer (NK) cell proliferation and activity | GAMIDA CELL LTD. (IL) | 2015-11-03 | — | — | US | disclosed |
| US-8927281-B2 | Method for expanding hematopoietic stem cells | IRM LLC (BM) | 2015-01-06 | — | — | US | disclosed |
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-12-18 | — | — | US | disclosed |
| EP-2788476-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | Fred Hutchinson Cancer Research Center (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-24 | — | — | US | disclosed |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| WO-2013086436-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2013-06-13 | — | — | WO | disclosed |
| EP-2350078-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2011-08-03 | — | — | EP | disclosed |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | CDK1 3739/4885CCNB1 2637/4885CDK5 3822/4885 |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CDK1 2794/4885CCNB1 2656/4885CDK5 4497/4885 |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CDK1 2794/4885CCNB1 2656/4885CDK5 4497/4885 |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CDK1 2794/4885CCNB1 2656/4885CDK5 4497/4885 |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | PBK, IL2, AHR | CDK1 2075/4885CCNB1 1309/4885CDK5 4004/4885 |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CDK1 2794/4885CCNB1 2656/4885CDK5 4497/4885 |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | AHR, HGF, MTNR1A | CDK1 4486/4885CCNB1 2218/4885CDK5 3149/4885 |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | CDK1 3739/4885CCNB1 2637/4885CDK5 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.