Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL231340 | 0.98 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL67551 | 0.98 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL67549 | 0.98 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27537584 | 0.98 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7949814 | 0.95 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28185469 | 0.95 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL9306995 | 0.93 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4981541 | 0.93 | LMNA (0.46) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL5175869 | 0.93 | LMNA (0.46) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL10836232 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973972-A | A kind of puncture-resistant thermal contraction double-walled pipe and preparation method thereof | 上海长园电子材料有限公司 | 2018-05-01 | — | — | CN | claimed |