Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5175869 | 1.00 | LMNA (0.46) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL27537584 | 0.95 | TSHR (0.45) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL231340 | 0.95 | TSHR (0.45) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL67551 | 0.95 | TSHR (0.45) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL67549 | 0.95 | TSHR (0.45) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28215238 | 0.93 | TSHR (0.43) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28185469 | 0.93 | TSHR (0.43) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL7949814 | 0.93 | TSHR (0.43) | LMNATSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL7631382 | 0.93 | LMNA (0.53) | LMNATSHRTP53ALDH1A1ALOX15 | |
| Acrylic Acid SCHEMBL211838 | 0.93 | LMNA (0.53) | LMNATSHRTP53ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280880-B1 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | PROCTER & GAMBLE (US) | 2008-10-29 | — | — | EP | disclosed |
| US-6740633-B2 | Polyelectrolyte complexes and a method for production thereof | BASF AKTIENGESELLSCHAFT (DE) | 2004-05-25 | — | — | US | disclosed |
| US-6596678-B2 | Polyelectrolyte complex of cationic adducts or polymers of (poly)amines crosslinked with epihalohydrins, and a polyanionic polymer such as polysodium acrylate | THE PROCTER & GAMBLE CO. | 2003-07-22 | — | — | US | disclosed |
| US-20030078185-A1 | Polyelectrolyte complexes and a method for production thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-04-24 | — | — | US | disclosed |
| EP-1280880-A2 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 2003-02-05 | — | — | EP | disclosed |
| US-20010056058-A1 | Laundry detergent compositions containing a polymer for fabric appearance improvement | THE PROCTER & GAMBLE COMPANY | 2001-12-27 | — | — | US | disclosed |
| WO-2001085891-A2 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |