Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | USP8 | P40818 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | USP4 | Q13107 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274539 | 0.80 | KMT2A (0.41) | ALDH1A1POLBKDM4EGAASLC6A2 | |
| SCHEMBL11373902 | 0.79 | USP2 (0.47) | USP2USP8USP5USP4USP7 | |
| SCHEMBL8131924 | 0.76 | NPC1 (0.53) | USP2USP8USP5USP4USP7 | |
| SCHEMBL11173991 | 0.75 | USP2 (0.56) | USP2USP8USP5USP4USP7 | |
| SCHEMBL98131 | 0.74 | TTR (0.48) | ALDH1A1KDM4EGAADRD2DRD3 | |
| SCHEMBL7760561 | 0.73 | IMPDH2 (0.37) | USP2USP8USP5USP4USP7 | |
| SCHEMBL10412909 | 0.73 | USP2 (0.60) | USP2USP8USP5USP4USP7 | |
| SCHEMBL352155 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL29443092 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL11277214 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109419802-B | Compounds having dopamine D3 receptor modulating activity and uses thereof | 中国人民解放军军事医学科学院毒物药物研究所（CN） | 2023-01-13 | — | — | CN | disclosed |
| EP-2354136-B1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-02-24 | — | — | EP | disclosed |
| US-9227944-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY SCIENCE P.L.A. CHINA (CN) | 2016-01-05 | — | — | US | disclosed |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2014-11-06 | — | — | US | disclosed |
| US-8829001-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A (CN) | 2011-12-29 | — | — | US | disclosed |
| CN-102264733-A | novel dopamine D3 receptor ligand, preparation method and medical application thereof | — | 2011-11-30 | — | — | CN | disclosed |
| EP-2354136-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS, THE PREPARATION AND USE THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2011-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | USP2 2907/4885USP8 3323/4885USP5 2349/4885 |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | USP2 2907/4885USP8 3323/4885USP5 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.