Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722557 | 0.83 | LTA4H (0.64) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL28320605 | 0.81 | LTA4H (0.62) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL28257875 | 0.81 | LTA4H (0.62) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL28362996 | 0.81 | LTA4H (0.62) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL12730052 | 0.79 | MGLL (0.50) | LTA4HHPGDSCA2CA1MGLL | |
| SCHEMBL2025419 | 0.78 | LTA4H (0.55) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| Hydrochloric Acid SCHEMBL9218418 | 0.76 | LTA4H (0.53) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL27529368 | 0.76 | LTA4H (0.53) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL17704300 | 0.75 | LTA4H (0.56) | LTA4HHPGDSHDAC4CHRNA7CHRNA10 | |
| SCHEMBL19949791 | 0.75 | HPGDS (0.39) | LTA4HHPGDSHDAC4BRD4ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046699-B2 | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses | RAPT THERAPEUTICS, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| EP-3802544-A1 | PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES | RAPT Therapeutics, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046699-B2 | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses | GLS, GLS2, TK2 | LTA4H 1251/4885HPGDS 75/4885CA2 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.