Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187646 | 0.82 | CYP2C19 (0.33) | — | |
| SCHEMBL30976095 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL30976129 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL30976214 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL30976245 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL30976172 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL30976195 | 0.82 | PLA2G2A (0.37) | KCNH2SIGMAR1 | |
| SCHEMBL32665610 | 0.81 | KIF11 (0.32) | KCNH2SIRT2 | |
| SCHEMBL30976149 | 0.81 | PLA2G2A (0.35) | KCNH2SIGMAR1 | |
| SCHEMBL19296711 | 0.79 | SIRT2 (0.41) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099384-A1 | THIOESTER CATIONIC LIPIDS | TRANSLATE BIO INC (US) | 2025-03-27 | — | — | US | disclosed |
| US-12076439-B2 | Thioester cationic lipids | TRANSLATE BIO, INC. (US) | 2024-09-03 | — | — | US | disclosed |
| CN-117430538-A | Thioester cationic lipids | 川斯勒佰尔公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437767-B | thioester cationic lipids | 川斯勒佰尔公司 | 2023-10-27 | — | — | CN | disclosed |
| US-20220008338-A1 | Thioester Cationic Lipids | TRANSLATE BIO, INC. | 2022-01-13 | — | — | US | disclosed |
| EP-3802487-A1 | THIOESTER CATIONIC LIPIDS | Translate Bio, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| CN-112437767-A | Thioester cationic lipids | 川斯勒佰尔公司 | 2021-03-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12076439-B2 | Thioester cationic lipids | CETP, LYPLA2, LYPLA1 | KCNH2 4133/4885DRD2 4799/4885OPRM1 4264/4885 |
| US-20250099384-A1 | THIOESTER CATIONIC LIPIDS | CETP, LYPLA2, LYPLA1 | KCNH2 4133/4885DRD2 4799/4885OPRM1 4264/4885 |
| US-20220008338-A1 | Thioester Cationic Lipids | CETP, LYPLA2, LYPLA1 | KCNH2 4133/4885DRD2 4799/4885OPRM1 4264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.