SCHEMBL2320172

SCHEMBL2320172

COc1ccc(-c2ccc(C=O)o2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.61
ALDH1A1 P00352 7/20 0.61
LMNA P02545 1/20 0.61
TDP1 Q9NUW8 1/20 0.56
MAPT P10636 5/20 0.54
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
GAA P10253 1/20 0.54
HSP90AA1 P07900 1/20 0.54
EGFR P00533 1/20 0.51
PKM P14618 2/20 0.51
STAT1 P42224 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
NQO2 P16083 2/20 0.49
CYP2A6 P11509 1/20 0.47
CYP3A4 P08684 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
CYP2E1 P05181 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8973988 0.98 KDM4E (0.59) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL396870 0.84 ALDH1A1 (0.80) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL8974039 0.84 ALDH1A1 (0.59) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL8974038 0.84 RXFP1 (0.48) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL3023711 0.81 MAPT (0.61) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL3037639 0.81 KDM4E (0.56) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL8974059 0.81 RXFP1 (0.42) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL2549273 0.80 PIK3CG (0.58) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL2318474 0.79 KDM4E (0.67) KDM4EALDH1A1LMNATDP1MAPT
SCHEMBL3038241 0.79 KDM4E (0.57) KDM4EALDH1A1LMNATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12378208-B2 N-substituted oseltamivir derivatives with antimicrobial activity THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2025-08-05 US disclosed
US-20250051638-A1 POWDERED FLUOROCHROME COMPOSITION, RESIN COMPOSITION, MOLDED ARTICLE, AND METHOD FOR PRODUCING POWDERED FLUOROCHROME COMPOSITION DIC CORPORATION (JP) 2025-02-13 US disclosed
US-20250011292-A1 NOVEL RHODANINE DERIVATIVES AND USES THEREOF GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2025-01-09 US disclosed
EP-4415704-A1 NOVEL RHODANINE DERIVATIVES AND USES THEREOF Georgia State University Research Foundation, Inc. (US) 2024-08-21 EP disclosed
CN-118434822-A Powdery pigment composition, method for producing powdery pigment composition, resin composition, and molded article DIC株式会社 2024-08-02 CN disclosed
WO-2023064368-A1 NOVEL RHODANINE DERIVATIVES AND USES THEREOF GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2023-04-20 WO disclosed
US-20220306592-A1 N-SUBSTITUTED OSELTAMIVIR DERIVATIVES WITH ANTIMICROBIAL ACTIVITY THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2022-09-29 US disclosed
CN-114286817-A N-substituted oseltamivir derivatives having antimicrobial activity 香港理工大学 2022-04-05 CN disclosed
EP-3059288-B1 RESIN COMPOSITION AND MOLDED ARTICLE DAINIPPON INK & CHEMICALS (JP) 2021-12-22 EP disclosed
US-20210030895-A1 RESIN COMPOSITION AND MOLDED ARTICLE DIC CORPORATION (JP) 2021-02-04 US disclosed
WO-2008005651-A2 CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS DECODE CHEMISTRY, INC. (US) 2008-01-10 WO disclosed
WO-2007121432-A2 BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-25 WO disclosed
US-20070244094-A1 BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL CYMABAY THERAPEUTICS, INC. 2007-10-18 US disclosed
US-20070244094-A1 BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL CYMABAY THERAPEUTICS, INC. 2007-10-18 US disclosed
EP-1697335-A1 FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2006-09-06 EP disclosed
WO-2005063727-A1 FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2005-07-14 WO disclosed
EP-0039892-B1 SUBSTITUTED PHENYL ETHERS CIBA-GEIGY AG (CH) 1986-12-30 EP disclosed
US-4559354-A ADRENERGIC BLOCKING AGENTS AND STIMULANTS; CARDIOTONIC, ANTIARRHYTHMIA AND INOTROPIC AGENTS CIBA-GEIGY CORPORATION (US) 1985-12-17 US disclosed
EP-0039892-A1 Substituted phenyl ethers CIBA-GEIGY AG (CH) 1981-11-18 EP disclosed
US-3946049-A 5-PHENYL-2-FURAMIDOXIMES MORTON-NORWICH PRODUCTS, INC. (US) 1976-03-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306592-A1 N-SUBSTITUTED OSELTAMIVIR DERIVATIVES WITH ANTIMICROBIAL ACTIVITY CTSA, MAVS, PNP KDM4E 4431/4885ALDH1A1 1013/4885LMNA 2317/4885
US-20210030895-A1 RESIN COMPOSITION AND MOLDED ARTICLE IK, CBR3, RER1 KDM4E 1200/4885ALDH1A1 643/4885LMNA 1854/4885
US-20070244094-A1 BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL PPARD, PPARG, PPARA KDM4E 4792/4885ALDH1A1 670/4885LMNA 2040/4885
US-12378208-B2 N-substituted oseltamivir derivatives with antimicrobial activity CTSA, MAVS, PNP KDM4E 4431/4885ALDH1A1 1013/4885LMNA 2317/4885
US-20250011292-A1 NOVEL RHODANINE DERIVATIVES AND USES THEREOF ACE2, RARG, ALAD KDM4E 4281/4885ALDH1A1 955/4885LMNA 4733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.