Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484847 | 0.84 | GSK3B (0.56) | MMP2MMP12GSK3B | |
| SCHEMBL10412424 | 0.81 | MAPT (0.52) | SMN1; SMN2MAPTL3MBTL1RAB9AATM | |
| SCHEMBL8049735 | 0.81 | ALDH1A1 (0.43) | SMN1; SMN2MAPTRAB9AHPGDMEN1 | |
| SCHEMBL19707521 | 0.80 | GSK3B (0.43) | SMN1; SMN2MAPTL3MBTL1RAB9AATM | |
| SCHEMBL9636621 | 0.79 | HPGD (0.47) | SMN1; SMN2MAPTL3MBTL1RAB9AHPGD | |
| SCHEMBL6036758 | 0.79 | RARB (0.55) | SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL19543261 | 0.79 | MAPT (0.50) | SMN1; SMN2MAPTL3MBTL1RAB9AATM | |
| SCHEMBL1348968 | 0.78 | CA12 (0.54) | SMN1; SMN2MAPTRAB9ANPC1HPGD | |
| SCHEMBL25093690 | 0.78 | NOS1 (0.44) | SMN1; SMN2MAPTL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL12692232 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPTL3MBTL1RAB9AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658644-B2 | Pyridazine derivatives, processes for their preparation and their use as fungicides | SYNGENTA CROP PROTECTION, LLC (US) | 2014-02-25 | — | — | US | disclosed |
| EP-2531491-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | Syngenta Participations AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-20120295876-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011095461-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295876-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | CYP4Z1, CYP4F3, CYP4F2 | SMN1; SMN2 4405/4885MAPT 4335/4885L3MBTL1 2698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.