Sugi Predict

Sugi Predict / Compounds / SCHEMBL9636621

SCHEMBL9636621

SCHEMBL9636621

CC(=O)c1ccc(C#C[Si](C)(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 4/20 0.47
▸ LMNA P02545 3/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ ACACB O00763 1/20 0.44
▸ NOS3 P29474 2/20 0.42
▸ NOS1 P29475 2/20 0.42
▸ MAPT P10636 4/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ HSD17B1 P14061 1/20 0.41
▸ GAA P10253 1/20 0.40
▸ BRD4 O60885 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8049735 0.86 ALDH1A1 (0.43) HPGDLMNAMAPTALDH1A1RAB9A
SCHEMBL6036758 0.84 RARB (0.55) HPGDACACBALDH1A1SMN1; SMN2RARB
SCHEMBL25093690 0.82 NOS1 (0.44) L3MBTL1NOS1MAPTALDH1A1KMT2A
SCHEMBL28655847 0.81 MMP2 (0.34) HPGDMAPTALDH1A1KMT2AKDM4E
SCHEMBL1306384 0.80 GABRA1 (0.38) HPGDLMNAMAPTALDH1A1RAB9A
SCHEMBL7262242 0.80 GABRA1 (0.31) HPGDALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL3941980 0.79 HDAC6 (0.50) HPGDACACBSMN1; SMN2RARBRARG
SCHEMBL5046534 0.79 ALDH1A1 (0.47) HPGDACACBALDH1A1KMT2ASMN1; SMN2
SCHEMBL28680590 0.79 ACACB (0.48) HPGDLMNAL3MBTL1ACACBNOS3
SCHEMBL2321185 0.79 SMN1; SMN2 (0.46) HPGDL3MBTL1MAPTALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2023-02-21 — — US disclosed
CN-115583902-A Preparation method of alkynyl thioether compound 江苏医药职业学院 2023-01-10 — — CN disclosed
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-01-06 — — US disclosed
EP-3556755-B1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2021-11-17 — — EP disclosed
EP-3556755-B1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2021-11-17 — — EP disclosed
CN-112313229-A Substituted aminothiazoles as inhibitors of nucleases 马萨里克大学 2021-02-02 — — CN disclosed
WO-2019201865-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2019-10-24 — — WO disclosed
WO-2019201865-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2019-10-24 — — WO disclosed
EP-3556755-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed
EP-3556755-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed
US-20160016895-A1 ANTIBACTERIAL AGENTS ACHAOGEN, INC. 2016-01-21 — — US disclosed
US-20150353546-A1 METALLOENZYME INHIBITOR COMPOUNDS Viamet Pharmaceuticals (NC), Inc. 2015-12-10 — — US disclosed
US-20150353546-A1 METALLOENZYME INHIBITOR COMPOUNDS Viamet Pharmaceuticals (NC), Inc. 2015-12-10 — — US disclosed
US-20150336894-A1 PEST CONTROL AGENT ISHIHARA SANGYO KAISHA, LTD. (JP) 2015-11-26 — — US disclosed
EP-2934137-A1 PEST CONTROL AGENT Ishihara Sangyo Kaisha, Ltd. (JP) 2015-10-28 — — EP disclosed
WO-2014117090-A1 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS, INC. (US) 2014-07-31 — — WO disclosed
WO-2014098259-A1 PEST CONTROL AGENT ISHIHARA SANGYO KAISHA, LTD. (JP) 2014-06-26 — — WO disclosed
EP-0372816-B1 NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-07-29 — — EP disclosed
WO-1990006304-A1 NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1990-06-14 — — WO disclosed
EP-0372816-A1 Novel heterocyclic pesticidal compounds THE WELLCOME FOUNDATION LIMITED (GB) 1990-06-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150353546-A1 METALLOENZYME INHIBITOR COMPOUNDS MMEL1, GPX1, MPO HPGD 571/4885LMNA 4266/4885L3MBTL1 1568/4885
US-20150336894-A1 PEST CONTROL AGENT DDT, CTRL, PTP4A1 HPGD 2292/4885LMNA 3744/4885L3MBTL1 1150/4885
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases RNASEH1, DNASE1, FEN1 HPGD 4259/4885LMNA 522/4885L3MBTL1 75/4885
US-20160016895-A1 ANTIBACTERIAL AGENTS MRPL21, ABCB11, LSS HPGD 593/4885LMNA 3308/4885L3MBTL1 2949/4885
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES RNASEH1, DNASE1, FEN1 HPGD 4259/4885LMNA 522/4885L3MBTL1 75/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.