SCHEMBL23213627

SCHEMBL23213627

Cc1c(Cl)cc([N+](=O)[O-])cc1CO

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
GPR35 Q9HC97 2/20 0.46
HTT P42858 2/20 0.44
POLB P06746 2/20 0.44
HSD17B10 Q99714 1/20 0.43
TSHR P16473 1/20 0.42
KMT2A Q03164 2/20 0.39
LMNA P02545 3/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.37
KDM4E B2RXH2 1/20 0.37
VCAM1 P19320 1/20 0.37
CYP19A1 P11511 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29716291 0.84 ALDH1A1 (0.52) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL23214233 0.84 ALDH1A1 (0.52) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL29796093 0.83 ALDH1A1 (0.43) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL23214060 0.83 ALDH1A1 (0.43) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL23213916 0.83 ALDH1A1 (0.50) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL29739336 0.83 ALDH1A1 (0.50) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL8818426 0.82 ALDH1A1 (0.64) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL23213701 0.82 ALDH1A1 (0.49) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL30407568 0.82 ALDH1A1 (0.49) ALDH1A1GPR35HTTPOLBHSD17B10
SCHEMBL1751440 0.81 ALDH1A1 (0.67) ALDH1A1GPR35HTTPOLBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12391663-B2 Isoindolinone compounds MONTE ROSA THERAPEUTICS AG (CH) 2025-08-19 US disclosed
US-20240308976-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND USES THEREOF MONTE ROSA THERAPEUTICS AG (CH) 2024-09-19 US disclosed
US-20240261274-A1 TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS MONTE ROSA THERAPEUTICS AG (CH) 2024-08-08 US disclosed
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2024-07-04 US disclosed
CN-117917402-A Isoindolylamide compound, and pharmaceutical composition and application thereof 暨南大学 2024-04-23 CN disclosed
US-20240083869-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS AG (CH) 2024-03-14 US disclosed
US-11912682-B2 Isoindolinone compounds MONTE ROSA THERAPEUTICS, INC. (US) 2024-02-27 US disclosed
EP-4323349-A1 ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 Monte Rosa Therapeutics AG (CH) 2024-02-21 EP disclosed
US-20240051937-A1 ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 MONTE ROSA THERAPEUTICS AG (CH) 2024-02-15 US disclosed
EP-4313047-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS Monte Rosa Therapeutics, Inc. (US) 2024-02-07 EP disclosed
EP-4277901-A1 ISOINDOLINONE COMPOUNDS Monte Rosa Therapeutics, Inc. (US) 2023-11-22 EP disclosed
US-20230348418-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS AG (CH) 2023-11-02 US disclosed
WO-2023069708-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND USES THEREOF MONTE ROSA THERAPEUTICS, INC. (US) 2023-04-27 WO disclosed
WO-2022219412-A1 ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 MONTE ROSA THERAPEUTICS AG (CH) 2022-10-20 WO disclosed
WO-2022200857-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2022-09-29 WO disclosed
EP-4041231-A1 ISOINDOLINONE COMPOUNDS Monte Rosa Therapeutics AG (CH) 2022-08-17 EP disclosed
US-20220242846-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS AG (CH) 2022-08-04 US disclosed
WO-2022152821-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS AG (CH) 2022-07-21 WO disclosed
WO-2022152822-A1 TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS MONTE ROSA THERAPEUTICS AG (CH) 2022-07-21 WO disclosed
WO-2021069705-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS (CH) 2021-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12391663-B2 Isoindolinone compounds CYP4F2, AOC2, AOC3 ALDH1A1 1142/4885GPR35 3797/4885HTT 4306/4885
US-20240083869-A1 ISOINDOLINONE COMPOUNDS CYP4F2, AOC2, AOC3 ALDH1A1 1142/4885GPR35 3797/4885HTT 4306/4885
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS UPF1, NSUN2, RTF2 ALDH1A1 4150/4885GPR35 4234/4885HTT 868/4885
US-20240051937-A1 ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 GSPT2, GSPT1, NMT2 ALDH1A1 2870/4885GPR35 939/4885HTT 3206/4885
US-20230348418-A1 ISOINDOLINONE COMPOUNDS CYP4F2, AOC2, AOC3 ALDH1A1 1370/4885GPR35 3743/4885HTT 4187/4885
US-20240308976-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND USES THEREOF CRBN, GSPT1, GSPT2 ALDH1A1 4088/4885GPR35 570/4885HTT 699/4885
US-20220242846-A1 ISOINDOLINONE COMPOUNDS AOC2, AOC3, INF2 ALDH1A1 1331/4885GPR35 4300/4885HTT 3454/4885
US-11912682-B2 Isoindolinone compounds CYP4F2, AOC2, AOC3 ALDH1A1 1142/4885GPR35 3797/4885HTT 4306/4885
US-20240261274-A1 TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS MYC, MYCBP, GSPT1 ALDH1A1 4276/4885GPR35 2597/4885HTT 835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.