Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217910 | 0.79 | CA12 (0.40) | TDP1KDM4E | |
| SCHEMBL29796592 | 0.76 | P2RX7 (0.38) | TGFBR1P2RX7NPC1GRM5ALPL | |
| SCHEMBL23389992 | 0.76 | P2RX7 (0.38) | TGFBR1P2RX7NPC1GRM5ALPL | |
| SCHEMBL4876970 | 0.72 | ALOX15 (0.55) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL4858870 | 0.69 | NPC1 (0.60) | TGFBR1ALDH1A1HPGDP2RX7NPC1 | |
| SCHEMBL23217923 | 0.69 | NPC1 (0.40) | TGFBR1ALDH1A1HPGDP2RX7NPC1 | |
| SCHEMBL6181864 | 0.68 | MAPT (0.48) | ALDH1A1HPGDP2RX7NPC1RAB9A | |
| SCHEMBL28527232 | 0.68 | HSD17B3 (0.44) | ALDH1A1GLAP2RX7NPC1RAB9A | |
| SCHEMBL359221 | 0.67 | ALDH1A1 (0.50) | ALDH1A1HPGDF2GLAMAPT | |
| SCHEMBL38217661 | 0.65 | CES2 (0.59) | ALDH1A1HPGDP2RX7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |