Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24311925 | 0.85 | DGAT1 (0.40) | DGAT1LIPGNPC1RAB9A | |
| SCHEMBL23217904 | 0.77 | CA1 (0.41) | CA1CA2CA9DGAT1HIF1A | |
| SCHEMBL18614454 | 0.75 | LPL (0.37) | DGAT1LIPGIDO1TDO2LPL | |
| SCHEMBL23218017 | 0.75 | HIF1A (0.39) | DGAT1HIF1AIDO1TDO2PRMT5 | |
| SCHEMBL1817315 | 0.74 | IRAK4 (0.47) | CA1CA2CA9LIPGIDO1 | |
| SCHEMBL13180214 | 0.73 | LPL (0.39) | DGAT1HIF1ALIPGIDO1TDO2 | |
| SCHEMBL1684672 | 0.73 | CA1 (0.61) | CA1CA2CA9LIPGCXCR2 | |
| SCHEMBL14022001 | 0.73 | LPL (0.39) | CA1CA2CA9LIPGIDO1 | |
| SCHEMBL2144580 | 0.72 | MTNR1A (0.42) | DGAT1HIF1AGSK3AGSK3BNPC1 | |
| SCHEMBL2144110 | 0.72 | MTNR1A (0.49) | CA1CA2CA9DGAT1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |