Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | CFD | P00746 | 6/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29592731 | 1.00 | MTNR1A (0.38) | MTNR1AMTNR1BCFDL3MBTL1ALDH1A1 | |
| SCHEMBL28736137 | 0.86 | CFD (0.47) | CFDL3MBTL1ALDH1A1DUSP3PTPN5 | |
| SCHEMBL29852707 | 0.81 | CFD (0.47) | MTNR1AMTNR1BCFD | |
| SCHEMBL23218462 | 0.81 | CFD (0.47) | MTNR1AMTNR1BCFD | |
| SCHEMBL29591859 | 0.81 | TBXAS1 (0.39) | CFDALDH1A1DUSP3PTPN5PTPN11 | |
| SCHEMBL23219118 | 0.81 | TBXAS1 (0.39) | CFDALDH1A1DUSP3PTPN5PTPN11 | |
| SCHEMBL23219189 | 0.79 | MTNR1A (0.34) | MTNR1AMTNR1BCFDL3MBTL1 | |
| SCHEMBL29853043 | 0.79 | MTNR1A (0.34) | MTNR1AMTNR1BCFDL3MBTL1 | |
| SCHEMBL28736277 | 0.79 | CFD (0.46) | CFDALDH1A1DUSP3PTPN5PTPN11 | |
| SCHEMBL23241696 | 0.76 | L3MBTL1 (0.37) | CFDL3MBTL1ALDH1A1DUSP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |