Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | CFD | P00746 | 8/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.30 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853043 | 1.00 | MTNR1A (0.34) | MTNR1AMTNR1BCFDCYP2C9PTGER1 | |
| SCHEMBL28736163 | 0.89 | CFD (0.42) | CFDPTGER1L3MBTL1 | |
| SCHEMBL29852833 | 0.85 | CFD (0.46) | MTNR1AMTNR1BCFD | |
| SCHEMBL23219227 | 0.85 | CFD (0.46) | MTNR1AMTNR1BCFD | |
| SCHEMBL23219064 | 0.79 | MTNR1A (0.38) | MTNR1AMTNR1BCFDL3MBTL1 | |
| SCHEMBL29592731 | 0.79 | MTNR1A (0.38) | MTNR1AMTNR1BCFDL3MBTL1 | |
| SCHEMBL23219053 | 0.73 | CFD (0.55) | CFDPTGER1 | |
| SCHEMBL29853068 | 0.73 | CFD (0.55) | CFDPTGER1 | |
| SCHEMBL23241696 | 0.73 | L3MBTL1 (0.37) | CFDCYP2C9L3MBTL1TBXAS1 | |
| SCHEMBL30009863 | 0.73 | L3MBTL1 (0.37) | CFDCYP2C9L3MBTL1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |