Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852848 | 1.00 | TBXAS1 (0.45) | TBXAS1KDM4ESMN1; SMN2RXFP1MAPT | |
| SCHEMBL28736155 | 0.86 | CFD (0.41) | CFDALDH1A1AHRGAAPTGER1 | |
| SCHEMBL2263014 | 0.83 | KDM4E (0.46) | KDM4ESMN1; SMN2RXFP1MAPTMEN1 | |
| SCHEMBL29852662 | 0.80 | CFD (0.56) | TBXAS1CFDSLC2A2MET | |
| SCHEMBL23219161 | 0.80 | CFD (0.56) | TBXAS1CFDSLC2A2MET | |
| SCHEMBL28742005 | 0.77 | KDM4E (0.43) | TBXAS1KDM4ESMN1; SMN2RXFP1MAPT | |
| SCHEMBL7890168 | 0.72 | TBXAS1 (0.59) | TBXAS1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23218817 | 0.71 | SLC2A2 (0.46) | TBXAS1KDM4ESMN1; SMN2MAPTCFD | |
| SCHEMBL29853185 | 0.71 | SLC2A2 (0.46) | TBXAS1KDM4ESMN1; SMN2MAPTCFD | |
| SCHEMBL16397226 | 0.71 | MAOB (0.53) | TBXAS1KDM4ESMN1; SMN2CFDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |