Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 3/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | CPA3 | P15088 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328940 | 0.83 | CYP1A2 (0.43) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL1915970 | 0.82 | CPA3 (0.56) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7321758 | 0.82 | TAAR1 (0.44) | CYP1A2CPA1CPB1CPA3CPB2 | |
| SCHEMBL28924046 | 0.82 | TRPA1 (0.64) | TRPA1ACE | |
| SCHEMBL10589550 | 0.80 | CYP1A2 (0.40) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL10799571 | 0.80 | CYP1A2 (0.40) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL28924048 | 0.78 | CTSK (0.45) | TRPA1MME | |
| SCHEMBL28924082 | 0.78 | TRPA1 (0.44) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL19812667 | 0.78 | EPHX1 (0.47) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7325384 | 0.78 | TSHR (0.50) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092831-A1 | Proteasome Inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2024-03-21 | — | — | US | disclosed |
| EP-4041747-A1 | PROTEASOME INHIBITORS | Mayo Foundation for Medical Education and Research (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021072212-A1 | PROTEASOME INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092831-A1 | Proteasome Inhibitors | PSMG3, PSMC5, PSMC1 | ALPI 2554/4885PKM 1815/4885PTGS1 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.