Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TAF1 | P21675 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29591435 | 1.00 | MAOA (0.42) | MAOAMAOBNFKB1TNFRIPK1 | |
| SCHEMBL1160167 | 0.73 | MAOA (0.47) | MAOAMAOBNFKB1HTR2CHTR2A | |
| SCHEMBL4923157 | 0.72 | MAOA (0.49) | MAOAMAOBNFKB1BRD4TAF1 | |
| SCHEMBL4420813 | 0.72 | DYRK1A (0.31) | — | |
| SCHEMBL4426880 | 0.71 | TNF (0.39) | MAOAMAOBTNFRIPK1HTR2C | |
| SCHEMBL4419365 | 0.71 | ALDH1A1 (0.42) | FTO | |
| SCHEMBL4429415 | 0.69 | PAX8 (0.48) | MAOAMAOBNFKB1HTR2CHTR2A | |
| SCHEMBL29591462 | 0.69 | TNF (0.54) | TNFRIPK1AHRPIM3BRD4 | |
| SCHEMBL1374474 | 0.69 | TNF (0.54) | TNFRIPK1AHRPIM3BRD4 | |
| SCHEMBL4420524 | 0.69 | HTR2C (0.37) | MAOAMAOBNFKB1HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |