Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455751 | 0.91 | ALDH1A1 (0.53) | ALDH1A1PPARGPOLBTDP1DPP4 | |
| SCHEMBL30482840 | 0.91 | ALDH1A1 (0.53) | ALDH1A1PPARGPOLBTDP1DPP4 | |
| SCHEMBL24200318 | 0.90 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1PPARGPOLB | |
| SCHEMBL23617308 | 0.88 | DPP4 (0.48) | ALDH1A1POLBTDP1DPP4MAPT | |
| SCHEMBL21455279 | 0.87 | ALDH1A1 (0.44) | ALDH1A1PPARGPOLBTDP1DPP4 | |
| SCHEMBL23229043 | 0.85 | HSD17B10 (0.62) | MTNR1AMTNR1BPOLBMAPTHSD17B10 | |
| SCHEMBL24200347 | 0.84 | ALDH1A1 (0.42) | MTNR1AMTNR1BALDH1A1PPARGPOLB | |
| SCHEMBL21561992 | 0.83 | NLRP3 (0.42) | ALDH1A1POLBDPP4MAPTHSD17B10 | |
| SCHEMBL12093646 | 0.83 | PPARG (0.48) | ALDH1A1PPARGMAPTHSD17B10MEN1 | |
| SCHEMBL23656671 | 0.82 | ALDH1A1 (0.41) | ALDH1A1PPARGPOLBTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687506-B1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |