Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.48 |
| ▸ | AR | P10275 | 4/20 | 0.45 |
| ▸ | ICMT | O60725 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23235782 | 0.99 | MRGPRX4 (0.47) | MRGPRX4ARICMTALDH1A1SMN1; SMN2 | |
| SCHEMBL29741540 | 0.88 | AR (0.45) | MRGPRX4ARICMTALDH1A1SLC6A4 | |
| SCHEMBL23566024 | 0.88 | AR (0.45) | MRGPRX4ARICMTALDH1A1SLC6A4 | |
| Hydrochloric Acid SCHEMBL29741557 | 0.87 | AR (0.44) | MRGPRX4ARICMTALDH1A1SLC6A4 | |
| SCHEMBL23235773 | 0.85 | MRGPRX4 (0.51) | MRGPRX4ARSLC6A4HTR6 | |
| Hydrochloric Acid SCHEMBL23235835 | 0.84 | MRGPRX4 (0.50) | MRGPRX4ARSLC6A4HTR6 | |
| SCHEMBL3490042 | 0.83 | MAOB (0.57) | MRGPRX4ARALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23540967 | 0.81 | MAOB (0.59) | AR | |
| SCHEMBL20076960 | 0.78 | MRGPRX4 (0.60) | MRGPRX4ARALDH1A1SMN1; SMN2SLC6A4 | |
| SCHEMBL6766128 | 0.77 | MAOB (0.57) | MRGPRX4ARALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230105108-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2023-04-06 | — | — | US | disclosed |
| EP-4076420-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | Georgia State University Research Foundation, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-114845708-A | Compounds for treating bacterial infections and enhancing antibiotics | 乔治亚州大学研究基金会 | 2022-08-02 | — | — | CN | disclosed |
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-10-07 | — | — | US | disclosed |
| WO-2021127452-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3806836-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | Georgia State University Research Foundation, Inc. (US) | 2021-04-21 | — | — | EP | disclosed |
| CN-112566631-A | Amidines and amidine analogs for the treatment of bacterial infections and potentiation of antibiotics | 乔治亚州大学研究基金会 | 2021-03-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | PAM, AMPD1, AMPD3 | MRGPRX4 546/4885AR 4411/4885ICMT 1977/4885 |
| US-20230105108-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | BPGM, MYD88, PGLS | MRGPRX4 1026/4885AR 4523/4885ICMT 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.