Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23246167 | 0.82 | SIRT6 (0.62) | NHERF1MCL1SIRT6ALDH1A1SMN1; SMN2 | |
| SCHEMBL28355424 | 0.82 | NHERF1 (0.43) | NHERF1MCL1SIRT6ALDH1A1TDP1 | |
| SCHEMBL29335293 | 0.74 | NHERF1 (0.55) | NHERF1MCL1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL23246177 | 0.71 | SIRT6 (0.49) | SIRT6CYP3A4POLB | |
| SCHEMBL23246160 | 0.70 | SIRT6 (0.67) | SIRT6TSHRLMNANPSR1 | |
| SCHEMBL23246166 | 0.70 | SIRT6 (0.44) | SIRT6ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL30218132 | 0.69 | TSHR (0.58) | NHERF1MCL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL23832700 | 0.69 | TSHR (0.58) | NHERF1MCL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10897052 | 0.68 | CYP3A4 (0.58) | ALDH1A1CYP3A4TDP1TSHRLMNA | |
| SCHEMBL23261491 | 0.67 | MAPT (0.39) | ALDH1A1CYP3A4TDP1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |