Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23260707 | 0.80 | SIRT6 (0.68) | SIRT6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23246177 | 0.77 | SIRT6 (0.49) | SIRT6POLB | |
| SCHEMBL23246160 | 0.76 | SIRT6 (0.67) | SIRT6BRD4GAA | |
| SCHEMBL23246171 | 0.70 | NHERF1 (0.47) | SIRT6ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL23261505 | 0.66 | POLB (0.50) | SIRT6ALDH1A1POLBSMN1; SMN2PKM | |
| SCHEMBL29561189 | 0.65 | SIRT6 (0.65) | SIRT6ALDH1A1CCR2GAAMAPT | |
| SCHEMBL10915039 | 0.63 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2MAPTKDM4E | |
| SCHEMBL10915888 | 0.63 | LMNA (0.50) | BRD4ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL23246167 | 0.63 | SIRT6 (0.62) | SIRT6BRD4ALDH1A1GAAPOLB | |
| SCHEMBL2120261 | 0.62 | KMT2A (0.52) | ALDH1A1POLBSMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |