Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.42 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23246166 | 0.83 | SIRT6 (0.44) | SIRT6SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL23246171 | 0.82 | NHERF1 (0.47) | NHERF1MCL1SIRT6NFKBIARELA | |
| SCHEMBL23260702 | 0.79 | TDP1 (0.39) | SMN1; SMN2LMNAMAPTHTTMEN1 | |
| SCHEMBL23246167 | 0.78 | SIRT6 (0.62) | NHERF1MCL1SIRT6NFKBIARELA | |
| SCHEMBL23260707 | 0.77 | SIRT6 (0.68) | SIRT6LMNAMAPTMEN1KMT2A | |
| SCHEMBL13253426 | 0.68 | TDP1 (0.56) | L3MBTL1LMNAMAPTHTTALDH1A1 | |
| SCHEMBL1744862 | 0.68 | ALDH1A1 (0.53) | L3MBTL1LMNAMAPTHTTMEN1 | |
| SCHEMBL30218132 | 0.68 | TSHR (0.58) | NHERF1MCL1NFKBIARELAGUSB | |
| SCHEMBL23832700 | 0.68 | TSHR (0.58) | NHERF1MCL1NFKBIARELAGUSB | |
| SCHEMBL7838979 | 0.66 | ALDH1A1 (0.55) | SMN1; SMN2L3MBTL1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |